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Fristam FDS Twin Screw Pump White Paper

Proven Gentle Handling for Biopharma, Pharmaceutical and Life Sciences Applications

The Fristam FDS Twin Screw Pump White Paper (2025), developed with the bioX Applications Lab, demonstrates why the Fristam FDS hygienic twin screw pump outperforms conventional technologies such as rotary lobe pumps and peristaltic pumps.

This independent study confirms that the Fristam FDS delivers:

  • Low shear pumping for shear-sensitive fluids
  • Less than 5% hemolysis in blood-handling applications
  • Superior protein stability, protecting Immunoglobulin G (IgG)
  • Pulse-free flow, ensuring consistency in chromatography and tangential flow filtration (TFF)

Why Choose the Fristam FDS Twin Screw Pump?

Low Shear for Bioprocessing
The FDS protects fragile biological products by minimising shear stress. This makes it ideal for cell culture transfer, vaccine processing, and monoclonal antibody (mAb) production.

FDS pump
FDS product details

Reduced Hemolysis
Laboratory testing confirmed under 5% hemolysis after two hours of continuous pumping — significantly lower than traditional pump technologies.

Protein Stability
When transferring IgG at 10 g/L, the FDS showed only a 4% reduction in protein concentration, compared with 8–16% losses in other pump designs.

Consistent, Low-Pulsation Flow
The twin screw design ensures smooth, reproducible flow — essential for chromatography and TFF.

Applications Across Industries

  • Pharmaceutical manufacturing – gentle pumping of proteins, enzymes, and APIs
  • Biotechnology – monoclonal antibodies, vaccines, sterile filtration and fermentation broths
  • Life sciences – blood, plasma, and cell therapy products
  • Cosmetics & personal care – viscous, particulate-rich, or shear-sensitive liquids

FAQ – Frequently Asked Questions about the FDS pump

What makes the Fristam FDS Twin Screw Pump different from rotary lobe pumps?

The Fristam FDS handles fluids with much lower shear stress, reducing hemolysis and protein denaturation. Independent testing showed less than 5% hemolysis compared to significantly higher rates in rotary lobe pumps.

Can the Fristam FDS Pump be used in monoclonal antibody production?

Yes. The low shear, gentle pumping action of the FDS preserves protein stability, making it a reliable choice for mAb production, vaccine transfer, and high-value biopharmaceutical applications.

How does the Fristam FDS improve chromatography and TFF processes?

The pump delivers pulse-free, consistent flow, reducing variability in tangential flow filtration (TFF) and chromatography systems, leading to better reproducibility and higher yield.

Is the Fristam FDS suitable for both single-use and multi-use bioprocessing?

Yes. The pump is designed for multi-use systems and can be adapted for single-use bioprocess skids, offering flexibility across aseptic and sterile applications.

Download the White Paper

The full Fristam FDS Twin Screw Pump White Paper includes detailed test data, methodology, and side-by-side comparisons with conventional pumps.

Download the white paper here

Looking to improve product quality, reduce shear stress, and protect valuable biomolecules?
Contact Fristam today to discuss how the FDS Double Screw Pump can optimise your pharmaceutical, biotechnology, and life science processes.